Targeting epidermal growth factor receptor: novel therapeutics in the management of cancer.
作者： Mazen Y Khalil , Jennifer R Grandis , Dong M Shin , None
关键词:
摘要: Overexpression of epidermal growth factor receptor (EGFR) in epithelial tumors, including head and neck, lung, breast, colon other solid has frequently been correlated with poor prognosis, thus stimulating efforts to develop new cancer therapies that target EGFR. Monoclonal antibodies tyrosine kinase inhibitors specifically targeting EGFR are the most well-studied hold substantial promise success. Several compounds monoclonal have studied clinical trials now underway test safety efficacy these strategies several human tumors. This review will address each agents alone or combination radiation chemotherapy highlight some promising developments. Cetuximab (Erbitux®) is being evaluated Phase III trials. Other such as h-R3, ABX-EGF, EMD-55900 ICR-62 proved be effective mali...
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