Topoisomerase 2 Alpha Cooperates with Androgen Receptor to Contribute to Prostate Cancer Progression

摘要: Overexpression of TOP2A is associated with risk systemic progression in prostate cancer patients, and higher levels were found hormone-resistant cases. To elucidate the mechanism by which high contribute to tumor we generated overexpressing cell lines. We show that promotes aggressiveness inducing chromosomal rearrangements genes a more invasive phenotype. Anti-androgen treatment alone was ineffective killing cells due activation an androgen receptor network. poisons killed efficiently early course, while at later stages they provided greater benefit when combined anti-androgen therapy. Mechanistically, find enhances signaling facilitating transcription responsive genes, thereby promoting growth. These studies revealed relationship between pathway contributes confers sensitivity treatments.