The regulation of hematopoietic stem cell and progenitor mobilization by chemokine SDF-1.

作者: Koichi Hattori , Beate Heissig , Shahin Rafii

DOI: 10.1080/1042819021000037985

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摘要: The chemokine, stromal derived factor-1 (SDF1) has been shown to modulate the homing of stem cells its site by mediating chemotaxis. We demontrated overexpression SDF-1 induced mobilization with cell potential (CFU-S, long-term reconstituting cells). Moreover, activated matrix metalloproteinase-9 in bone marrow (BM) cells, causing release soluble Kit-ligand and permitting transfer hematopoietic (HSCs) from a quiescent proliferative niche. role process HSC migration mechanism underlying this HSCs will be reviewed. These studies lay foundation for using induce progenitor BM transplantation setting.

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