EDR is a stress-related survival factor from stroma and other tissues acting on early haematopoietic progenitors (E-Mix).
作者： Peter Dörmer , Elisabeth Spitzer , Winfried Möller
DOI: 10.1016/J.CYTO.2004.03.014
关键词:
摘要: The erythroid differentiation regulator (EDR) is a highly conserved autocrine factor produced in many tissues. Its haemoglobin synthesis-inducing activity for human and murine erythroleukaemia cell lines had been detected WEHI-3 conditioned medium. EDR functions were analysed detail. It released from cells immediately response to various stressful conditions enhances survival particularly at lower concentration range low density. At high density the opposite effect of an increase death was observed. essential function within tissue considered be maintenance growth homeostasis. Cells kept culture weeks show decreasing responsiveness supply. This also noted freshly cloned EDR-responsive mouse pointing molecular adaptation process. Human haematopoietic progenitors amplified 7-fold by when cytokine levels. saturating levels giving rise least two lineages semisolid medium (E-mix) respond with average 1.87-fold colony numbers bell-shaped dose-response curve. Of more mature BFU-E compartment observed cases numbers. Given release irradiated stromal ability partly substitute Burkitt's lymphoma line BL-70, as stroma-responsive cells.
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