Genetic alterations in sporadic and Crohn's-associated adenocarcinomas of the small intestine
作者： A Rashid , SR Hamilton
DOI: 10.1016/S0016-5085(97)70087-8
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摘要: Abstract BACKGROUND & AIMS: Small intestinal carcinomas are rare but occur with increased incidence in Crohn's disease. The aim of this study was to elucidate the genetic alterations. METHODS: Mutations and deletions involved colorectal carcinoma were studied sporadic Crohn's- associated precursors. RESULTS: c-K-ras mutations present all four contiguous adenomas, only 18% without adenomas (P = 0.01), 43% carcinomas, 14% dysplasias. Overexpression p53 gene product and/or 17p allelic loss 47% 33% 71% In contrast, losses 5q (adenomatous polyposis coli [APC] region) 18q (deleted cancer [DCC] rare. DNA replication errors (RERs) 13% dysplasias 1 patient disease (14%), transforming growth factor beta type II receptor (TGFbeta RII) absent. CONCLUSIONS: Accumulation ras alterations occurs during adenoma/dysplasia-carcinoma sequence small carcinogenesis, a ras-independent pathway may also exist. infrequent APC DCC regions absence TGFbeta RII mutation RER-positive neoplasms contrast carcinogenesis. (Gastroenterology 1997 Jul;113(1):127-35)
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