The systemic inflammatory response, weight loss, performance status and survival in patients with inoperable non-small cell lung cancer.
作者： H R Scott , D C McMillan , L M Forrest , D J F Brown , C S McArdle
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摘要: The relationship between the magnitude of systemic inflammatory response and nutritional/functional parameters in patients with inoperable non-small cell lung cancer were studied. extent weight loss, albumin, C-reactive protein, performance status quality life was measured 106 (stages III IV). Survival analysis performed using Cox proportional hazard model. majority male almost 80% had elevated circulating protein concentrations (>10 mg x l(-1)). On multivariate analysis, age (P=0.012), tumour type (0.002), loss (P=0.056), (P=0.047), Karnofsky (P=0.002) fatigue (P=0.046) independent predictors survival. grouped according to ( 100 An increase associated increased (P=0.004), reduced albumin (P=0.001), (P=0.060), (P=0.011) survival (HR 1.936 95%CI 1.414-2.650, P<0.001). These results indicate that have evidence a response. Furthermore, an resulted greater poorer status, more
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