Zebrafish genetics and formation of embryonic vasculature.
作者： Tao P. Zhong
DOI: 10.1016/S0070-2153(05)71002-4
关键词:
摘要: The embryonic vasculature develops in a conserved manner all vertebrates. Endothelial progenitor cells differentiate from mesodermal cells, then migrate and assemble into the dorsal aorta cardinal vein. This primitive circulatory loop undergoes sprouting branching via two-step navigation mechanism to form trunk vascular network. Various studies using several model systems have uncovered number of signaling mechanisms that regulate these complex processes. A genetic approach zebrafish has led identification mutations molecules are responsible for specification endothelial differentiation arterial venous patterning intersegmental vessels. These highlight unique utilities benefits system studying development blood
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