Dietary Phytoestrogen Intake Is Associated with Reduced Colorectal Cancer Risk

摘要: Evidence suggests dietary phytoestrogens may reduce the risk of certain hormonal cancers (e.g. breast and prostate). There is a paucity data regarding colorectal cancer risk. Phytoestrogens are plant compounds with estrogen-like activities. Main classes include isoflavones (found in legumes such as soy) lignans grains, seeds, nuts, fruits, vegetables). Although have dominated phytoestrogen research, be more relevant to North American diets. Food questionnaires analytic databases recently been modified incorporate some lignan information. We conducted case-control study evaluate association between intake Colorectal cases were diagnosed 1997-2000, aged 20-74 y, identified through population-based Ontario Cancer Registry, recruited by Familial Registry. Controls sex age-group matched random sample population Ontario. Epidemiologic food frequency completed 1095 1890 control subjects. Multivariate logistic regression analysis was used obtain adjusted odds ratio (OR) estimates. Dietary associated significant reduction [OR (T3 vs. T1) = 0.73; 95% CI: 0.56, 0.94], isoflavone 0.71; 0.58, 0.86]. evaluated interactions polymorphic genes that encode enzymes possibly involved metabolism (CYPs, catechol O-methyl transferase, GSTs, UGTs) found no effect modification respect intake. This finding important, because potentially modifiable.