Antimicrobial activity of gentamicin and vancomycin combination in joint fluids after antibiotic-loaded cement spacer implantation in two-stage revision surgery
作者： Elisa. Bertazzoni Minelli , Anna. Benini , Elena. Samaila , Manuel. Bondi , Bruno. Magnan
DOI: 10.1179/1973947813Y.0000000157
关键词:
摘要: Gentamicin (G) and vancomycin (V) concentrations in joints fluids obtained from patients during the first 24 hours after implantation of antibiotic-loaded polymethylmethacrylate (PMMA) spacers two-stage revision for infected arthroplasty, inhibitory activity joint against different multiresistant clinical isolates were studied. A total 12 undergoing surgery with industrial G added amounts V was Serum fluid samples collected 1, 4, spacer implantation. Antibiotics bactericidal titer (JBT) combination determined staphylococcal strains. The local release PMMA cement seemed prompt effective. levels below limit detection. same showed according to susceptibility pathogens tested. released at exerting a strong inhibition methicillin-resistant Staphylococcus aureus (MRSA) coagulase-negative staphylococci (CoNS)
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researchgate.net 参考文章(23)
Werner Zimmerli, Andrej Trampuz, Implant-Associated Infection Biofilm Infections. pp. 69- 90 ,(2011) , 10.1007/978-1-4419-6084-9_5
B. Magnan, D. Regis, A. Costa, P. Bartolozzi, Two-stage Revision of Infected Total Hip Replacement Using a Preformed, Antibiotic-loaded Acrylic Cement Spacer Infection and Local Treatment in Orthopedic Surgery. pp. 205- 213 ,(2007) , 10.1007/978-3-540-47999-4_25
Mary Jane. Ferraro, Methods for dilution antimicrobial susceptibility tests for bacteria that grow aerobically NCCLS. ,(2000)
E. Bertazzoni Minelli, T. Della Bora, A. Benini, Different microbial biofilm formation on polymethylmethacrylate (PMMA) bone cement loaded with gentamicin and vancomycin. Anaerobe. ,vol. 17, pp. 380- 383 ,(2011) , 10.1016/J.ANAEROBE.2011.03.013
Alejandro González Della Valle, Mathias Bostrom, Barry Brause, Carolyn Harney, Eduardo A Salvati, Effective bactericidal activity of tobramycin and vancomycin eluted from acrylic bone cement Acta Orthopaedica Scandinavica. ,vol. 72, pp. 237- 240 ,(2001) , 10.1080/00016470152846547
Jens Kelm, Thilo Regitz, Eduard Schmitt, Werner Jung, Konstantinos Anagnostakos, In Vivo and In Vitro Studies of Antibiotic Release from and Bacterial Growth Inhibition by Antibiotic-Impregnated Polymethylmethacrylate Hip Spacers Antimicrobial Agents and Chemotherapy. ,vol. 50, pp. 332- 335 ,(2006) , 10.1128/AAC.50.1.332-335.2006
Karthikeyan P. Iyengar, Sobhan Vinjamuri, Role of 99mTc Sulesomab in the diagnosis of prosthetic joint infections. Nuclear Medicine Communications. ,vol. 26, pp. 489- 496 ,(2005) , 10.1097/00006231-200506000-00003
Peng Wu, David W. Grainger, Drug/device combinations for local drug therapies and infection prophylaxis. Biomaterials. ,vol. 27, pp. 2450- 2467 ,(2006) , 10.1016/J.BIOMATERIALS.2005.11.031
Konstantinos Anagnostakos, Philippe Wilmes, Eduard Schmitt, Jens Kelm, Elution of gentamicin and vancomycin from polymethylmethacrylate beads and hip spacers in vivo Acta Orthopaedica. ,vol. 80, pp. 193- 197 ,(2009) , 10.3109/17453670902884700
David Fuster, Alex Soriano, Sebastian Garcia, Carlos Piera, Joan Suades, Dani Rodríguez, Juan C. Martinez, Josep Mensa, Francisco Campos, Francesca Pons, Usefulness of 99mTc-ciprofloxacin scintigraphy in the diagnosis of prosthetic joint infections. Nuclear Medicine Communications. ,vol. 32, pp. 44- 51 ,(2011) , 10.1097/MNM.0B013E328340E6FB