Phenotype and distribution pattern of nestin-GFP-expressing cells in murine myenteric plexus

摘要: The enteric nervous system has to adapt altering dietary or environmental conditions and presents an enormous plasticity that is conserved over the whole lifespan. It harbours neural-crest-derived neurons, glial cells their precursors. Based on a nestin-green fluorescent protein (NGFP) transgenic model, histological inventory been performed deliver overview of neuronal markers for various parts gastrointestinal tract in newborn (postnatal day 7) adult mice under homeostatic conditions. Whereas NGFP-positive can be found all gut at any individual age, specific NGFP population present with both morphology marker expression myenteric plexus (nNGFP). These appear variable quantities, depending age location. Their overall abundance decreases from adults spatial distribution also age-dependent. In gut, nNGFP are similar quantities throughout significantly lower presence duodenum. increases mouse stomach colon. All these expressed either (but not both) glia S100 fibrillary acidic (GFAP). S100-positive population, subset shows (nS100), without expressing nestin. Thus, premature neurons express demonstrates neurogenesis takes place far beyond birth. acts as showing differentiation change phenotype precursor cells.