Distribution of the intermediate filament nestin in the muscularis propria of the human gastrointestinal tract.
作者： Jean-Marie Vanderwinden , Karine Gillard , Conrad Messam , Serge Schiffmann , Marc-Henri De Laet
DOI: 10.1007/S00441-002-0590-3
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摘要: The intermediate filament nestin is expressed in neural stem cells, neuroectodermal tumors and various adult tissues. In the gastrointestinal (GI) tract, has been reported glial cells. Recently, interstitial cells of Cajal (ICC) stromal tumors, thought to derive from ICC. Here we investigated immunoreactivity (-ir) normal human GI with emphasis on Kit-ir Two different antibodies specific for multicolor high-resolution confocal microscopy were used material our tissue collection. staining pattern both was similar. labeled nestin-ir appeared filamentous. Most intramuscular ICC antrum all myenteric (ICC-MP) small intestine nestin-ir, while not detected deep muscular plexus colon, some - but ICC-MP most circular musculature longitudinal submuscular plexus. addition, many Kit-negative regions. Neurons smooth muscle consistently negative, S100-ir nestin-ir. also present CD34-ir fibroblast-like endothelium other cell types mucosa serosa. conclusion, abundantly tract. Among a number types, several, all, subpopulations functional significance tract remains obscure.
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S Nemecek, J Mokrý, Cerebral angiogenesis shows nestin expression in endothelial cells. General Physiology and Biophysics. pp. 25- 29 ,(1999)
J J Vanderhaeghen, J M Vanderwinden, S N Schiffmann, M H De Laet, J J Rumessen, CD34+ cells in human intestine are fibroblasts adjacent to, but distinct from, interstitial cells of Cajal. Laboratory Investigation. ,vol. 79, pp. 59- 65 ,(1999)
Takashi Tohyama, VM-Y Lee, LB Rorke, M Marvin, RD McKay, JQ Trojanowski, None, Nestin expression in embryonic human neuroepithelium and in human neuroepithelial tumor cells. Laboratory Investigation. ,vol. 66, pp. 303- 313 ,(1992)
J Frisén, C B Johansson, C Török, M Risling, U Lendahl, Rapid, widespread, and longlasting induction of nestin contributes to the generation of glial scar tissue after CNS injury. Journal of Cell Biology. ,vol. 131, pp. 453- 464 ,(1995) , 10.1083/JCB.131.2.453
Ervin Y Eaker, Judith E Sallustio, The distribution of novel intermediate filament proteins defines subpopulations of myenteric neurons in rat intestine Gastroenterology. ,vol. 107, pp. 666- 674 ,(1994) , 10.1016/0016-5085(94)90113-9
Samuli Vaittinen, Riitta Lukka, Cecilia Sahlgren, Jussi Rantanen, Timo Hurme, Urban Lendahl, John E. Eriksson, Hannu Kalimo, Specific and Innervation-Regulated Expression of the Intermediate Filament Protein Nestin at Neuromuscular and Myotendinous Junctions in Skeletal Muscle American Journal of Pathology. ,vol. 154, pp. 591- 600 ,(1999) , 10.1016/S0002-9440(10)65304-7
Urban Lendahl, Lyle B. Zimmerman, Ronald D.G. McKay, CNS stem cells express a new class of intermediate filament protein. Cell. ,vol. 60, pp. 585- 595 ,(1990) , 10.1016/0092-8674(90)90662-X
Scott R. Clarke, Ashok K. Shetty, Jennifer L. Bradley, Dennis A. Turner, Reactive astrocytes express the embryonic intermediate neurofilament nestin Neuroreport. ,vol. 5, pp. 1885- 1888 ,(1994) , 10.1097/00001756-199410000-00011
Tohru Tsujimura, Chiaki Makiishi-Shimobayashi, Johan Lundkvist, Urban Lendahl, Keiji Nakasho, Ayako Sugihara, Teruo Iwasaki, Masayuki Mano, Naoko Yamada, Kunihiro Yamashita, Akihiro Toyosaka, Nobuyuki Terada, Expression of the Intermediate Filament Nestin in Gastrointestinal Stromal Tumors and Interstitial Cells of Cajal The American Journal of Pathology. ,vol. 158, pp. 817- 823 ,(2001) , 10.1016/S0002-9440(10)64029-1
Janette M. Krum, Jeffrey M. Rosenstein, Transient coexpression of nestin, GFAP, and vascular endothelial growth factor in mature reactive astroglia following neural grafting or brain wounds. Experimental Neurology. ,vol. 160, pp. 348- 360 ,(1999) , 10.1006/EXNR.1999.7222