Curcumin Induces Human Colon Cancer Cell death via p62/SQSTM1 Degradation, Phospho-ERK Up-regulation and Ceramide Generation

Siraj Pallichankandy , Faisal Thayyullathil , Shahanas Chathoth , Abdulkader Hago
Current Trends in Biotechnology and Pharmacy 6 ( 4) 407 -417

2
2012
Critical role of H2O2 in mediating sanguinarine-induced apoptosis in prostate cancer cells via facilitating ceramide generation, ERK1/2 phosphorylation, and Par-4 cleavage.

Anees Rahman , Siraj Pallichankandy , Faisal Thayyullathil , Sehamuddin Galadari
Free Radical Biology and Medicine 134 527 -544

43
2019
Par-4 regulates autophagic cell death in human cancer cells via upregulating p53 and BNIP3.

Faisal Thayyullathil , Anees Rahman Cheratta , Siraj Pallichankandy , Karthikeyan Subburayan
Biochimica et Biophysica Acta 1867 ( 7) 118692

13
2020
Par-4-dependent p53 up-regulation plays a critical role in thymoquinone-induced cellular senescence in human malignant glioma cells.

Karthikeyan Subburayan , Faisal Thayyullathil , Siraj Pallichankandy , Anees Rahman
Cancer Letters 426 80 -97

26
2018
Superoxide-mediated ferroptosis in human cancer cells induced by sodium selenite.

Karthikeyan Subburayan , Faisal Thayyullathil , Siraj Pallichankandy , Anees Rahman Cheratta
Translational Oncology 13 ( 11) 100843

30
2020
Caspase-3 mediated release of SAC domain containing fragment from Par-4 is necessary for the sphingosine-induced apoptosis in Jurkat cells

Faisal Thayyullathil , Siraj Pallichankandy , Anees Rahman , Jaleel Kizhakkayil
Journal of Molecular Signaling 8 ( 1) 2 -2

19
2013
Prostate apoptosis response-4 and tumor suppression: it's not just about apoptosis anymore.

Anees Rahman Cheratta , Faisal Thayyullathil , Siraj Pallichankandy , Karthikeyan Subburayan
Cell Death and Disease 12 ( 1) 47 -47

2021
Acid sphingomyelinase-dependent autophagic degradation of GPX4 is critical for the execution of ferroptosis.

Faisal Thayyullathil , Anees Rahman Cheratta , Ameer Alakkal , Karthikeyan Subburayan
Cell Death and Disease 12 ( 1) 26 -26

33
2021
Tumor suppressive functions of ceramide: evidence and mechanisms

Sehamuddin Galadari , Anees Rahman , Siraj Pallichankandy , Faisal Thayyullathil
Apoptosis 20 ( 5) 689 -711

56
2015
Molecular targets and anticancer potential of sanguinarine—a benzophenanthridine alkaloid

Sehamuddin Galadari , Anees Rahman , Siraj Pallichankandy , Faisal Thayyullathil
Phytomedicine 34 143 -153

28
2017
Sphingosine analogue FTY720 sensitizes arsenic trioxide-induced autophagic cell death in human malignant glioma cells

Sehamuddin Galadari , Siraj Pallichankandy , Anees Rahman , Faisal Thayyullathil
Hamdan Medical Journal 10 ( 1) 39

2017
ROS-dependent activation of autophagy is a critical mechanism for the induction of anti-glioma effect of sanguinarine

Siraj Pallichankandy , Anees Rahman , Faisal Thayyullathil , Sehamuddin Galadari
Free Radical Biology and Medicine 89 708 -720

47
2015
Hydrogen peroxide/ceramide/Akt signaling axis play a critical role in the antileukemic potential of sanguinarine.

Anees Rahman , Faisal Thayyullathil , Siraj Pallichankandy , Sehamuddin Galadari
Free Radical Biology and Medicine 96 273 -289

35
2016
Reactive oxygen species and cancer paradox: To promote or to suppress?

Sehamuddin Galadari , Anees Rahman , Siraj Pallichankandy , Faisal Thayyullathil
Free Radical Biology and Medicine 104 144 -164

723
2017
Role of ceramide in diabetes mellitus: evidence and mechanisms

Sehamuddin Galadari , Anees Rahman , Siraj Pallichankandy , Alaa Galadari
Lipids in Health and Disease 12 ( 1) 98 -98

110
2013
Sanguinarine induces H2O2-dependent apoptosis and ferroptosis in human cervical cancer

Ameer Alakkal , Faisal Thayyullathil , Siraj Pallichankandy , Karthikeyan Subburayan
Biomedicines 10 ( 8) 1795

3
2022
Targeting oxeiptosis-mediated tumor suppression: a novel approach to treat colorectal cancers by sanguinarine

Siraj Pallichankandy , Faisal Thayyullathil , Anees Rahman Cheratta , Karthikeyan Subburayan
Cell Death Discovery 9 ( 1) 94

2023
Caspase cleavage and nuclear retention of the energy sensor AMPK-α1 during apoptosis

Anees Rahman Cheratta , Faisal Thayyullathil , Simon A Hawley , Fiona A Ross
Cell reports 39 ( 5)

14
2022
Tumor suppressor Par-4 activates autophagy-dependent ferroptosis

Karthikeyan Subburayan , Faisal Thayyullathil , Siraj Pallichankandy , Anees Rahman Cheratta
Communications Biology 7 ( 1) 732 -732

2024