Unique clinicopathologic features characterize ALK-rearranged lung adenocarcinoma in the western population.

摘要: Purpose: The anaplastic large cell kinase gene ( ALK ) is rearranged in ∼5% of lung adenocarcinomas within the Asian population. We evaluated incidence and characteristics -rearranged western population optimal diagnostic modality to detect rearrangements routine clinical practice. Experimental Design: tested 358 from three institutions for by fluorescent situ hybridization (FISH) immunohistochemistry with without tyramide amplification. clinicopathologic tumors were compared. Results: identified 20 (5.6%) our cohort patients. rearrangement was associated younger age P = 0.0002), never smoking 0.0001), a solid histology signet-ring cells FISH 95% cases amplification 80% 40% cases, respectively, but neither nor alone detected all on initial screening. None harbored coexisting EGFR mutations. Conclusions: Lung are uncommon represent distinct entity carcinomas unique characteristics. For suspected dual testing, immunohistochemistry, should be considered accurately identify rearrangement. (Clin Cancer Res 2009;15(16):5216–23)