Deletion mapping of the medulloblastoma locus on chromosome 17p.
作者： Philip H. Cogen , Laleh Daneshvar , Andrew K. Metzger , Michael S.B. Edwards
DOI: 10.1016/0888-7543(90)90283-Z
关键词: Medulloblastoma 、 Restriction fragment length polymorphism 、 Biology 、 Isochromosome 、 Locus (genetics) 、 Allele 、 Deletion mapping 、 Cancer research 、 Genetics 、 Chromosome 、 Chromosomal region
摘要: Isochromosome 17q has previously been observed consistently in cytogenetic studies of medulloblastoma, the most common posterior fossa neoplasm children. We performed a restriction fragment length polymorphism (RFLP) investigation medulloblastoma which showed loss chromosome 17p sequences 45% these tumors. This finding was predictive poor clinical response to treatment. A contiguous panel markers permitted mapping deletion 17p12-p13.1, same chromosomal region for alleles shown tumor specimens from patients with colon cancer, and p53 gene mapped. suggests that is associated recessive oncogene on may be involved genesis several embryologically unrelated neoplasms absence this tissue prognostic significance.
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