Evidence that genetic instability occurs at an early stage of colorectal tumorigenesis.
作者： Bert Vogelstein , Kenneth W. Kinzler , Steven N. Goodman , Wei Zhou , Ie-Ming Shih
DOI:
关键词: Adenomatous polyposis coli 、 Adenoma 、 Allele 、 Chromosome 、 Biology 、 Genetics 、 Allelic Imbalance 、 Chromosome instability 、 Tumor suppressor gene 、 Cancer research 、 Carcinogenesis
摘要: … have studied a series of colorectal adenomas averaging 2 mm in … that CIN occurs early during colorectal tumorigenesis. … less well defined than in colorectal tumorigenesis, such studies …
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