Comparing whole genomes using DNA microarrays
作者： David Gresham , Maitreya J. Dunham , David Botstein
DOI: 10.1038/NRG2335
关键词: Genetic variability 、 Biology 、 Genome variation 、 Microarray 、 Genetics 、 Genome 、 Computational biology 、 Intraindividual comparison 、 DNA microarray 、 Genetics(clinical) 、 Molecular biology
摘要: The rapid accumulation of complete genomic sequences offers the opportunity to carry out an analysis inter- and intra-individual genome variation within a species on routine basis. Sequencing whole genomes requires resources that are currently beyond those single laboratory therefore it is not practical approach for resequencing hundreds individual genomes. DNA microarrays present alternative way study differences between closely related Advances in microarray-based approaches have enabled main forms (amplifications, deletions, insertions, rearrangements base-pair changes) be detected using techniques readily performed laboratories simple experimental approaches.
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