Overexpression of Cyclin D1 in Epithelial Ovarian Cancers
作者： Sally D. Worsley , Bruce A.J. Ponder , Barry R. Davies
关键词: Regulation of gene expression 、 Cancer research 、 Cyclin A2 、 Cyclin D 、 Biology 、 Cyclin D1 、 Estrogen receptor 、 Cyclin B 、 Carcinogenesis 、 Oncogene
摘要: Amplification and overexpression of the cell cycle-related gene cyclin D1 have been demonstrated in several human malignancies shown to be directly oncogenic breast epithelium lymphocytes. Overexpression can occur absence amplification. We investigated whether is overexpressed a panel 43 sporadic epithelial ovarian cancers using immunohistochemistry. Cyclin was 26% these tumors. associated with borderline or well-differentiated, grade 1 tumors but does not correlate particular histological type, c-erb-B2 oncogene, presence estrogen receptors. It suggested that may contribute pathogenesis cancers, including subset different from those overexpressing oncogene.
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