Evolution of EV71 genogroup in Taiwan from 1998 to 2005: an emerging of subgenogroup C4 of EV71.

摘要: In Taiwan, enterovirus 71 (EV71) has played an important role in severe enterovirus-related cases every year since the devastating outbreak 1998. Three genogroups A, B, C occur worldwide; with B and being subdivided into B1-B4 C1-C4 subgenogroups respectively. To understand mutation of EV71 genogroup Taiwan before after 1998, a total 54 worldwide strains were studied including 41 Taiwanese obtained 1986 1998-2004. A fragment 207 bp VP4 region was amplified sequenced. Genetic analysis performed using MEGA software (version 3.0) for nucleotide sequence alignment phylogenetic analysis. subgenogroup B1 predominant 1998 while C2 major etiologic group outbreak. minor B4, became during period from 1999 to 2003. this study, C4 emerged 2004 Taiwan. The differences between C2, B4 20%-26%, 19%-27%, 18%-22%, Nucleotide revealed 67 substitutions. Most substitutions (62/67) silent mutations. This is first report about emergence