2-alkoxypropenals as synthetic equivalents of methylglyoxal in the synthesis of heterocycles
作者： N. A. Keiko , N. V. Vchislo , L. I. Larina
DOI: 10.1134/S1070428013030196
关键词: Cycloaddition 、 Methylglyoxal 、 Chemistry 、 Equivalent 、 Pyridine 、 Hydrolysis 、 Organic chemistry
摘要: One-pot synthesis of 2-methylquinoxaline, 3-hydroxy-2-methylimidazo[1,2-a]pyridine, and 2-methyl-3,7-dihydroimidazo[1,2-a]pyrazin-3-one via cycloaddition N,N-binucleophilic o-phenylenediamine, 2-aminopyridine, 2-aminopyrazine, respectively, to methylglyoxal generated in situ by hydrolysis 2-alkoxypropenals is reported for the first time. Thus weakly acidic medium (25–80°C, 1–4 h) are convenient synthetic equivalents heterocyclic compounds.
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