Epidermal growth factor receptor immunoreactivity in human laryngeal squamous cell carcinoma
作者： C. Soon Lee , Anna Redshaw , Guy Boag
DOI: 10.1080/00313029700169005
关键词: Tyrosine kinase 、 Immunohistochemistry 、 Epidermal growth factor receptor 、 Malignant transformation 、 Immunostaining 、 Growth factor receptor 、 Biology 、 Epidermoid carcinoma 、 Epidermal growth factor 、 Pathology
摘要: SummaryEpidermal growth factor receptor (EGFR) is a transmembrane protein with tyrosine kinase activity. The has cysteine-rich sequence repeats in its extracellular ligand-binding domains. Elevated levels of EGFR are associated malignant transformation squamous cells and observed cell carcinomas from the lung, head, neck, skin, cervix esophagus. We examined expression laryngeal carcinoma (SCC) (N = 24) non-neoplastic polyps 7) using streptavidin-biotin immunohistochemistry monoclonal antibody (Serotec: MCA-571) to protein. were classified as well differentiated 2), moderately 16) poorly 6). Tissues metastatic tumor deposits lymph nodes 5) also studied. Overexpression was present, form strong cytoplasmic immunostaining, majority SCC cases (n 20; 83%) all deposits. I...
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