The effect of body weight on progression of knee osteoarthritis is dependent on alignment.

摘要: Objective Whereas obesity increases overall loading of the knee, limb malalignment concentrates that on a focal area, to level at which cartilage damage may occur. This study evaluated whether effect body weight progression knee osteoarthritis (OA) differs depending degree malalignment. Methods The population comprised 228 veterans and community recruits with symptomatic OA (pain most days radiographic disease) who volunteered participate in natural history from whom baseline radiographs were obtained assess alignment; 227 (99.6%) completed 30-month followup. Of 403 knees assessed baseline, 394 (97.8%) followed up. Participants' mass index (BMI) was each examination. The main outcome measure OA, defined as narrowing tibiofemoral joint space by 1 grade (semiquantitative scale 0–3) fluoroscopically positioned knee. association between BMI risk after adjusting for age, sex, alignment, using logistic regression generalized estimating equations. Results Of knees, 90 (22.8%) showed disease progression, alignment strongly associated risk. increased increasing (for 2-unit increase BMI, odds ratio [OR] 1.08, 95% confidence interval [95% CI] 1.00–1.16). However, among those neutral (0–2°), had no (OR 1.00), severe (≥7°), similarly null 0.93). limited there moderate per 1.23, CI 1.05–1.45). Conclusion Although elevated is exists, presumably because combined focus load excess weight. has implications clinical recommendations trials testing loss OA.