Chemotherapy for Colorectal Cancer

作者: Alastair J.J. Wood , Charles G. Moertel

DOI: 10.1056/NEJM199404213301608

关键词: Colorectal cancerMedicineCarcinomaCombined Modality TherapyCause of deathLung cancerInternal medicineSurgeryRadiation therapyChemotherapyOncologyCancer

摘要: Carcinoma of the large bowel, which will afflict over 150,000 Americans this year, is second only to lung cancer as a cause death from cancer1. Although most patients present with surgically resectable disease, almost half die cancer. Radiation therapy has largely palliative role. In past, chemotherapy resulted in infrequent and usually transient shrinkage tumor, scarcely justifying discomforts costs treatment. recent years, however, there have been some advances. discussion that follows, credence given therapeutic claims validated by controlled trials sufficiently long . . .

参考文章(49)
Survival after postoperative combination treatment of rectal cancer. The New England Journal of Medicine. ,vol. 315, pp. 1294- 1295 ,(1986) , 10.1056/NEJM198611133152014
Khandan K. Keyomarsi, Richard G. Moran, Folinic acid augmentation of the effects of fluoropyrimidines on murine and human leukemic cells. Cancer Research. ,vol. 46, pp. 5229- 5235 ,(1986)
William T. Wynn, Daniele Szapary, James A. Straw, Pharmacokinetics of the Diastereoisomers of Leucovorin after Intravenous and Oral Administration to Normal Subjects Cancer Research. ,vol. 44, pp. 3114- 3119 ,(1984)
N Wolmark, H Rockette, D L Wickerham, B Fisher, C Redmond, E R Fisher, M Potvin, R J Davies, J Jones, A Robidoux, Adjuvant therapy of Dukes' A, B, and C adenocarcinoma of the colon with portal-vein fluorouracil hepatic infusion: preliminary results of National Surgical Adjuvant Breast and Bowel Project Protocol C-02. Journal of Clinical Oncology. ,vol. 8, pp. 1466- 1475 ,(1990) , 10.1200/JCO.1990.8.9.1466
P Rougier, A Laplanche, M Huguier, J M Hay, J M Ollivier, J Escat, R Salmon, M Julien, J C Roullet Audy, D Gallot, Hepatic arterial infusion of floxuridine in patients with liver metastases from colorectal carcinoma: long-term results of a prospective randomized trial. Journal of Clinical Oncology. ,vol. 10, pp. 1112- 1118 ,(1992) , 10.1200/JCO.1992.10.7.1112
M A Poon, M J O'Connell, H S Wieand, J E Krook, J B Gerstner, L K Tschetter, R Levitt, C G Kardinal, J A Mailliard, Biochemical modulation of fluorouracil with leucovorin: confirmatory evidence of improved therapeutic efficacy in advanced colorectal cancer. Journal of Clinical Oncology. ,vol. 9, pp. 1967- 1972 ,(1991) , 10.1200/JCO.1991.9.11.1967
M A Poon, M J O'Connell, C G Moertel, H S Wieand, S A Cullinan, L K Everson, J E Krook, J A Mailliard, J A Laurie, L K Tschetter, Biochemical modulation of fluorouracil: evidence of significant improvement of survival and quality of life in patients with advanced colorectal carcinoma. Journal of Clinical Oncology. ,vol. 7, pp. 1407- 1418 ,(1989) , 10.1200/JCO.1989.7.10.1407
H C Stevenson, I Green, J M Hamilton, B A Calabro, D R Parkinson, Levamisole: known effects on the immune system, clinical results, and future applications to the treatment of cancer. Journal of Clinical Oncology. ,vol. 9, pp. 2052- 2066 ,(1991) , 10.1200/JCO.1991.9.11.2052