Atherosclerosis and extracellular matrix.
作者： Shogo Katsuda , Toshiyuki Kaji
DOI: 10.5551/JAT.10.267
关键词: Lipoprotein 、 Intracellular 、 Enzyme 、 Cell biology 、 Cell migration 、 Pathology 、 Elastin 、 Matrix metalloproteinase 、 Extracellular matrix 、 Chemistry 、 Glycoprotein
摘要: Atherosclerosis is primarily a lesion that progresses due to series of reactions are induced by repair injured intima. The intercellular networking occurs among smooth muscle cells, macrophages, T lymphocytes and endothelial cells leads fibroproliferative response, in which the extracellular matrix (ECM) plays an important role. ECM, composed mixture vastly different macromolecules including collagen, elastin, glycoproteins proteoglycans, confers tensile strength viscoelasticity arterial wall. Each component ECM possesses unique structural properties determine its own roles during development atherosclerotic plaques. Not only does provide integrity plaques, but it also participates several key events such as cell migration proliferation, lipoprotein retention thrombosis. various metalloproteinases (MMPs), major enzymes degradation, their inhibitors (tissue MMPs) demonstrated plaque. An excess MMPs over contributes significantly destruction rendering plaque more prone rupture. Accumulating information on molecular regulation synthesis degradation will help investigators attain thorough understanding mechanisms formation instability
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