Relationships between promoter polymorphisms in the thymidylate synthase gene and mRNA levels in colorectal cancers

摘要: Thymidylate synthase (TS) intratumoural expression may be a prognostic marker and predict outcome of 5-fluorouracil (5-FU)-based chemotherapy in colorectal cancer patients. The TS gene promoter enhancer region contains two different polymorphisms which can influence mRNA transcriptional translational efficiency: polymorphic tandem repeat sequence (2 or 3 repeats; 2R 3R) single nucleotide polymorphism (SNP), G > C, within the second 3R alleles. We studied relationship between tumoural levels colonic mucosa 48 3R/3R genotype was characterised by higher tumour than 2R/2R-2R/3R genotypes (P = 0.071). Regarding with SNP polymorphism, statistically significant difference 3RG/3RG 2R/2R-2R/3RC-2R/3RG subset observed 0.017). No correlation experimental data baseline clinical-pathological characteristics as well clinical relatively small patient series investigated. This is first study reporting an association intra-repeat These results suggest that patients, C important factor determining levels, warrant further investigation role predictors sensitivity to 5-FU-based larger case series.