What brings pericytes to tumor vessels

作者: Michael F. Booth , Rakesh K. Jain

DOI: 10.1172/JCI20087

关键词: EndotheliumBlood vessel maturationParacrine signallingCancer researchGrowth factorBiologyMural cellPDGFBVascular endothelial growth factor BVascular endothelial growth factor A

摘要: … yet these tumor vessels are profoundly leaky (18). Is it possible that the tumor vessel–associated MCs increase the vessel … In addition to controlling vessel function and integrity, do these …

参考文章(18)
Timothy P. Padera, Dai Fukumura, Ananth Kadambi, Peter Carmeliet, Dennis E. J. G. J. Dolmans, Rakesh K. Jain, Chae-ok Yun, Carla Mouta Carreira, Vascular endothelial growth factor (VEGF)-C differentially affects tumor vascular function and leukocyte recruitment: role of VEGF-receptor 2 and host VEGF-A. Cancer Research. ,vol. 61, pp. 2404- 2408 ,(2001)
Edward B. Brown, Robert B. Campbell, Yoshikazu Tsuzuki, Lei Xu, Peter Carmeliet, Dai Fukumura, Rakesh K. Jain, In vivo measurement of gene expression, angiogenesis and physiological function in tumors using multiphoton laser scanning microscopy Nature Medicine. ,vol. 7, pp. 864- 868 ,(2001) , 10.1038/89997
S. K. Hobbs, W. L. Monsky, F. Yuan, W. G. Roberts, L. Griffith, V. P. Torchilin, R. K. Jain, Regulation of transport pathways in tumor vessels: Role of tumor type and microenvironment Proceedings of the National Academy of Sciences of the United States of America. ,vol. 95, pp. 4607- 4612 ,(1998) , 10.1073/PNAS.95.8.4607
Laura E. Benjamin, Dragan Golijanin, Ahuva Itin, Dov Pode, Eli Keshet, Selective ablation of immature blood vessels in established human tumors follows vascular endothelial growth factor withdrawal Journal of Clinical Investigation. ,vol. 103, pp. 159- 165 ,(1999) , 10.1172/JCI5028
Shunichi Morikawa, Peter Baluk, Toshiyuki Kaidoh, Amy Haskell, Rakesh K. Jain, Donald M. McDonald, Abnormalities in Pericytes on Blood Vessels and Endothelial Sprouts in Tumors American Journal of Pathology. ,vol. 160, pp. 985- 1000 ,(2002) , 10.1016/S0002-9440(10)64920-6
Peter Carmeliet, Angiogenesis in health and disease. Nature Medicine. ,vol. 9, pp. 653- 660 ,(2003) , 10.1038/NM0603-653
Christer Betsholtz, Alexandra Abramsson, Per Lindblom, Endothelial and nonendothelial sources of PDGF-B regulate pericyte recruitment and influence vascular pattern formation in tumors Journal of Clinical Investigation. ,vol. 112, pp. 1142- 1151 ,(2003) , 10.1172/JCI18549
Rakesh K Jain, Molecular regulation of vessel maturation. Nature Medicine. ,vol. 9, pp. 685- 693 ,(2003) , 10.1038/NM0603-685
Dai Fukumura, Ramnik Xavier, Takeyuki Sugiura, Yi Chen, Eun-Chung Park, Naifang Lu, Martin Selig, Gunnlaugur Nielsen, Tatyana Taksir, Rakesh K Jain, Brian Seed, Tumor Induction of VEGF Promoter Activity in Stromal Cells Cell. ,vol. 94, pp. 715- 725 ,(1998) , 10.1016/S0092-8674(00)81731-6