Identification of fusion genes in breast cancer by paired-end RNA-sequencing
作者： Henrik Edgren , Astrid Murumagi , Sara Kangaspeska , Daniel Nicorici , Vesa Hongisto
关键词: Genetics 、 Phenotype 、 Cancer 、 Fusion gene 、 Oncogene Fusion 、 Intron 、 Transcriptome 、 Biology 、 Human genetics 、 Gene expression profiling
摘要: Background Until recently, chromosomal translocations and fusion genes have been an underappreciated class of mutations in solid tumors. Next-generation sequencing technologies provide opportunity for systematic characterization cancer cell transcriptomes, including the discovery expressed resulting from underlying genomic rearrangements.
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