Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence.
作者： E Hara , R Smith , D Parry , H Tahara , S Stone
DOI: 10.1128/MCB.16.3.859
关键词: RNA 、 Cyclin-dependent kinase 6 、 Molecular biology 、 Cell culture 、 Transcription (biology) 、 Biology 、 Population 、 Retinoblastoma protein 、 Cell cycle 、 E2F
摘要: p16CDKN2 specifically binds to and inhibits the cyclin-dependent kinases CDK4 and CDK6, which function as regulators of cell cycle progression in G1 by contributing to the …
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