Ethanol and Natural Killer Cells. I. Activity and Immunophenotype in Alcoholic Humans
作者： Robert T. Cook , Feng Li , Daniel Vandersteen , Zuhair K. Ballas , Brian L. Cook
DOI: 10.1111/J.1530-0277.1997.TB04240.X
关键词: Immunophenotyping 、 Cluster of differentiation 、 Lymphocyte 、 CD19 、 Natural killer cell 、 Liver disease 、 Cellular immunity 、 Alcoholic liver disease 、 Immunology 、 Biology
摘要: The human lymphocyte fraction with the greatest fresh killing activity against K562 targets is phenotypically CD3 - CD19 CD56 + subset. There have been reports of reduced natural killer (NK) in alcoholics, but overall consistency lacking and phenotypic monitoring has inadequate to allow reliable estimates changes active cell fractions. We evaluated a range surface markers NK controls now report abnormalities In both phenotype function some normal profile others. Patients without evidence liver disease (AWLDs) tend basal activities profiles. alcoholic (ALDs) fewer Lin lymphocytes that are . Three 14 ALDs assayed present work had absent activity, whereas others were activated. AWLDs, presence monocytes lytic assay consistently inhibits lysis; but, patients ALD, stimulatory activity. alcoholics as one group, there statistically significant relative increase novel subset unknown function; this CD45RO
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