Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway.

作者: Dan Xie , Yi Xin Zeng , Hai Jun Wang , Lai Shan Tai , Jian Ming Wen

DOI: 10.1007/S00401-005-1072-Y

关键词: Epidermal growth factor receptorCancer researchAge of onsetAstrocytomaPathologyTp53 mutationGeneMutationBiologyChromosome instabilityPathological

摘要: It is believed that there are two distinct pathological pathways leading to the development of human glioblastomas (GBM) in Caucasian populations. Primary (de novo) GBM most often occurs older individuals, and characterized by overexpression/amplification epidermal growth factor receptor gene (EGFR), whereas secondary GBM, which progresses from a low-grade astrocytoma, affects younger individuals frequently contains TP53 mutation. We others have previously found age onset Chinese patients tends be than patients. To identify whether GBMs share this common pattern genetic alterations, expression levels EGFR mutation were analyzed 56 randomly selected (30 primary 26 secondary), including 47 adult-onset 9 pediatric GBMs. Consistent with other studies, overexpression/mutation aneuploid DNA content more detected adult In contrast observed patients, no significant difference was distribution frequency between Furthermore, overexpression much higher late-onset (age >45 years) (73%) both early-onset 18–45 (17%) <18 (11%), suggesting may associated closely but not tumors’ pathway.

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