The clinicopathologic values of the molecules associated with the main pathogenesis of the glioblastoma.
作者： Bomi Kim , Jae Kyung Myung , Ja Hee Seo , Chul-Kee Park , Sun Ha Paek
DOI: 10.1016/J.JNS.2010.03.019
关键词:
摘要: Abstract Glioblastoma (GBM) is a malignant CNS neoplasm. The prognosis of GBM may be influenced by the molecules p53/MDM2/p14ARF, RB/p16INK4a, and EGFR/PTEN/protein kinase B (PKB)/phosphoinositide 3-kinase (PI3K) pathways. We studied expression status specific molecular markers in GBMs immunohistochemistry (IHC) FISH correlation with clinical outcomes. positivity EGFR those IHC pharmDx Zymed antibodies were 64.9%, 73.5%, 43.4%, respectively. antibody was more sensitive but less than antibody. p53 overexpression, MDM2 expression, p16 loss, PTEN PKB PI3K found 48.2%, 26.5%, 56.6%, 21.4%, 15.7% 6.0%, significantly, although not completely, correlated immunoexpression also showed positive correlation. On multivariate survival studies, old age (≥ 40 yrs) bilaterality independent unfavorable factors ( p = 0.031).
elsevier.com
sci-hub.se 参考文章(25)
David N. Louis, WHO classification of tumours of the central nervous system International Agency for Research on Cancer. ,(2007)
Jon C. Aster, Abul K. Abbas, Vinay Kumar, James A. Perkins, Robbins & Cotran Pathologic Basis of Disease ,(2004)
A.P. Dei Tos, I. Ellis, Assessing epidermal growth factor receptor expression in tumours: What is the value of current test methods? European Journal of Cancer. ,vol. 41, pp. 1383- 1392 ,(2005) , 10.1016/J.EJCA.2005.03.018
B.K. Kleinschmidt-DeMasters, Lynne Meltesen, Loris McGavran, Kevin O. Lillehei, Characterization of Glioblastomas in Young Adults Brain Pathology. ,vol. 16, pp. 273- 286 ,(2006) , 10.1111/J.1750-3639.2006.00029.X
Yoon Kyung Jeon, Sook-Whan Sung, Jin-Haeng Chung, Weon-Seo Park, Jeong-Wook Seo, Chul Woo Kim, Doo Hyun Chung, Clinicopathologic features and prognostic implications of epidermal growth factor receptor (EGFR) gene copy number and protein expression in non-small cell lung cancer Lung Cancer. ,vol. 54, pp. 387- 398 ,(2006) , 10.1016/J.LUNGCAN.2006.08.015
Abbey Marquez, Rina Wu, Jianxin Zhao, Jianhua Tao, Zuorong Shi, Evaluation of epidermal growth factor receptor (EGFR) by chromogenic in situ hybridization (CISH) and immunohistochemistry (IHC) in archival gliomas using bright-field microscopy. Diagnostic Molecular Pathology. ,vol. 13, pp. 1- 8 ,(2004) , 10.1097/00019606-200403000-00001
Federico Cappuzzo, Fred R. Hirsch, Elisa Rossi, Stefania Bartolini, Giovanni L. Ceresoli, Lynne Bemis, Jerry Haney, Samir Witta, Kathleen Danenberg, Irene Domenichini, Vienna Ludovini, Elisabetta Magrini, Vanesa Gregorc, Claudio Doglioni, Angelo Sidoni, Maurizio Tonato, Wilbur A. Franklin, Lucio Crino, Paul A. Bunn, Marileila Varella-Garcia, Epidermal Growth Factor Receptor Gene and Protein and Gefitinib Sensitivity in Non–Small-Cell Lung Cancer Journal of the National Cancer Institute. ,vol. 97, pp. 643- 655 ,(2005) , 10.1093/JNCI/DJI112
Heikki Joensuu, Marjut Puputti, Harri Sihto, Olli Tynninen, Nina N Nupponen, Amplification of genes encoding KIT, PDGFRα and VEGFR2 receptor tyrosine kinases is frequent in glioblastoma multiforme The Journal of Pathology. ,vol. 207, pp. 224- 231 ,(2005) , 10.1002/PATH.1823
Dan Xie, Yi Xin Zeng, Hai Jun Wang, Lai Shan Tai, Jian Ming Wen, Yu Tao, Ning Fang Ma, Liang Hu, Jonathan S. T. Sham, Xin Yuan Guan, Amplification and overexpression of epidermal growth factor receptor gene in glioblastomas of Chinese patients correlates with patient's age but not with tumor's clinicopathological pathway. Acta Neuropathologica. ,vol. 110, pp. 481- 489 ,(2005) , 10.1007/S00401-005-1072-Y
Anne F. Buckley, Lawrence J. Burgart, Vaibhav Sahai, Sanjay Kakar, Epidermal growth factor receptor expression and gene copy number in conventional hepatocellular carcinoma. American Journal of Clinical Pathology. ,vol. 129, pp. 245- 251 ,(2008) , 10.1309/WF10QAAED3PP93BH