Identification of a 251 Gene Expression Signature That Can Accurately Detect M. tuberculosis in Patients with and without HIV Co-Infection
作者： Noor Dawany , Louise C. Showe , Andrew V. Kossenkov , Celia Chang , Prudence Ive
DOI: 10.1371/JOURNAL.PONE.0089925
关键词: Immunology 、 Mycobacterium tuberculosis 、 In patient 、 Coinfection 、 Gene expression 、 Cause of death 、 Tuberculosis diagnosis 、 Tuberculosis 、 Virology 、 Gene expression profiling 、 Biology 、 General Biochemistry, Genetics and Molecular Biology 、 General Agricultural and Biological Sciences 、 General Medicine
摘要: Background Co-infection with tuberculosis (TB) is the leading cause of death in HIV-infected individuals. However, diagnosis TB, especially presence an HIV co-infection, can be limiting due to high inaccuracy associated use conventional diagnostic methods. Here we report a gene signature that identify infection patients co-infected as well absence HIV.
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plosone.org参考文章(34)
Global Tuberculosis Programme, Global tuberculosis control : WHO report WHO Global Tuberculosis Programme. ,(1997)
Francesca Conradie, Andrea S. Foulkes, Prudence Ive, Xiangfan Yin, Katerina Roussos, Deborah K. Glencross, Denise Lawrie, Wendy Stevens, Luis J. Montaner, Ian Sanne, Livio Azzoni, Natural killer cell activation distinguishes Mycobacterium tuberculosis-mediated immune reconstitution syndrome from chronic HIV and HIV/MTB coinfection. Journal of Acquired Immune Deficiency Syndromes. ,vol. 58, pp. 309- 318 ,(2011) , 10.1097/QAI.0B013E31822E0D15
Madhukar Pai, Alice Zwerling, Dick Menzies, Systematic review: T-cell-based assays for the diagnosis of latent tuberculosis infection: an update. Annals of Internal Medicine. ,vol. 149, pp. 177- 184 ,(2008) , 10.7326/0003-4819-149-3-200808050-00241
Vladimir Mikhailovich, Dmitry Gryadunov, Alexander Kolchinsky, Alexander A. Makarov, Alexander Zasedatelev, DNA microarrays in the clinic: infectious diseases BioEssays. ,vol. 30, pp. 673- 682 ,(2008) , 10.1002/BIES.20781
Weerawat Manosuthi, Suthat Chottanapand, Supeda Thongyen, Achara Chaovavanich, Somnuek Sungkanuparph, Survival rate and risk factors of mortality among HIV/tuberculosis-coinfected patients with and without antiretroviral therapy. Journal of Acquired Immune Deficiency Syndromes. ,vol. 43, pp. 42- 46 ,(2006) , 10.1097/01.QAI.0000230521.86964.86
Promod K. Mehta, Ankush Raj, Netrapal Singh, Gopal K. Khuller, Diagnosis of extrapulmonary tuberculosis by PCR. Fems Immunology and Medical Microbiology. ,vol. 66, pp. 20- 36 ,(2012) , 10.1111/J.1574-695X.2012.00987.X
Sujit Suchindran, Emily S. Brouwer, Annelies Van Rie, Is HIV Infection a Risk Factor for Multi-Drug Resistant Tuberculosis? A Systematic Review PLoS ONE. ,vol. 4, pp. e5561- ,(2009) , 10.1371/JOURNAL.PONE.0005561
Helen McShane, Co-infection with HIV and TB: double trouble International Journal of Std & Aids. ,vol. 16, pp. 95- 101 ,(2005) , 10.1258/0956462053057576
Andrew V. Kossenkov, Anil Vachani, Celia Chang, Calen Nichols, Shere Billouin, Wenhwai Horng, William N. Rom, Steven M. Albelda, Michael K. Showe, Louise C. Showe, Resection of Non–Small Cell Lung Cancers Reverses Tumor-Induced Gene Expression Changes in the Peripheral Immune System Clinical Cancer Research. ,vol. 17, pp. 5867- 5877 ,(2011) , 10.1158/1078-0432.CCR-11-0737
Christopher Dye, Global epidemiology of tuberculosis. The Lancet. ,vol. 367, pp. 938- 940 ,(2006) , 10.1016/S0140-6736(06)68384-0