Signals adapting the beta cells to changes in insulin sensitivity

摘要: Insulin sensitivity and secretion are related in a curvilinear inverse asymptotic function. However, the signaling factors mediating this relation not known. In study, we explored whether circulating glucose, lipids or two adipocyte-derived hormones, leptin adiponectin, to function between insulin subjects with normal glucose tolerance. Thereby, (2-5-min response intravenous arginine) (euglycemic, hyperinsulinemic clamp) were established 68 healthy women, aged 61 years. We confirmed (r = -0.71, P < 0.001). To quantify ability of beta cells secrete for balancing change sensitivity, introduce cell compensation index (BCI) by dividing sensitivity. This correlated significantly triglycerides, adiponectin as well BMI, but fasting 2-h glucose. A multivariate stepwise regression analysis using these variables independent lg BCI dependent variable revealed that 0.54, 0.001) -0.33, 0.008) independently contributed (R-2 model 0.19m, 0.038). The therefore, suggests hormones contribute resistance. (C) 2002 Elsevier Science B.V. All rights reserved. (Less)