Core–shell drug carrier from folate conjugated chitosan obtained from prawn shell for targeted doxorubicin delivery
作者： Md Sazedul Islam , Papia Haque , Taslim U Rashid , M Nuruzzaman Khan , Abul K Mallik
DOI: 10.1007/S10856-017-5859-X
关键词: Nuclear chemistry 、 Superparamagnetism 、 Nanoparticle 、 Iron oxide nanoparticles 、 Doxorubicin 、 Nanomaterials 、 Materials science 、 Chitosan 、 Conjugated system 、 Drug carrier
摘要: A multifunctional drug carrier with dual targeting (magnetic and folate-receptor) pH sensitive core-shell hybrid nanomaterial has been developed to carry an anticancer doxorubicin.Superparamagnetic iron oxide nanoparticles (IONPs) were used as core of the cross-linked folate conjugated chitosan (FA-CS) was acted shell in which doxorubicin physically entrapped. Transmission electron microscopy (TEM) analysis confirmed average particle size IONPs FA-CS coated 8.2 15.4 nm respectively. Magnetic measurement indicated that both superparamagnetic at room temperature a magnetization value 57.72 37.44 emu/g respectively. At 5.8 (malignant tissue) showed burst release 30.05% first 4 h followed by sustained 88.26% over 72 h. From these results it is expected loaded can be promising for treatment solid tumors ability reduce toxic side effects drugs selective release.
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