Rho GTPases in neurodegeneration diseases.
作者： Jonathan DeGeer , Nathalie Lamarche-Vane
DOI: 10.1016/J.YEXCR.2013.06.016
关键词: Neural development 、 Cell biology 、 GTPase 、 Neurodegeneration 、 Intracellular 、 Rho GTPases 、 Cell 、 Biology 、 Effector 、 Function (biology)
摘要: Rho GTPases are molecular switches that modulate multiple intracellular signaling processes by means of various effector proteins. As a result, GTPase activities tightly spatiotemporally regulated in order to ensure homeostasis within the cell. Though roles during neural development have been well documented, their participation neurodegeneration has far less characterized. Herein we discuss our current knowledge role and function regulators neurodegeneration, highlight potential as targets for therapeutic intervention common neurodegenerative disorders.
sci-hub.se 参考文章(116)
Krister Wennerberg, Marie-Annick Forget, Shawn M Ellerbroek, William T Arthur, Keith Burridge, Jeffrey Settleman, Channing J Der, Steen H Hansen, Rnd proteins function as RhoA antagonists by activating p190 RhoGAP. Current Biology. ,vol. 13, pp. 1106- 1115 ,(2003) , 10.1016/S0960-9822(03)00418-4
Prashant Mandela, Xin-Ming Ma, Kalirin, a Key Player in Synapse Formation, Is Implicated in Human Diseases Neural Plasticity. ,vol. 2012, pp. 728161- 728161 ,(2012) , 10.1155/2012/728161
Katya J Park, Carlos Ayala Grosso, Isabelle Aubert, David R Kaplan, Freda D Miller, p75NTR-dependent, myelin-mediated axonal degeneration regulates neural connectivity in the adult brain Nature Neuroscience. ,vol. 13, pp. 559- 566 ,(2010) , 10.1038/NN.2513
Steven Petratos, Qiao-Xin Li, Amee J. George, Xu Hou, Megan L. Kerr, Sharon E. Unabia, Irene Hatzinisiriou, Danuta Maksel, Marie-Isabel Aguilar, David H. Small, The β-amyloid protein of Alzheimer's disease increases neuronal CRMP-2 phosphorylation by a Rho-GTP mechanism Brain. ,vol. 131, pp. 90- 108 ,(2008) , 10.1093/BRAIN/AWM260
Kevin C. Wang, Jieun A. Kim, Rajeev Sivasankaran, Rosalind Segal, Zhigang He, P75 interacts with the Nogo receptor as a co-receptor for Nogo, MAG and OMgp. Nature. ,vol. 420, pp. 74- 78 ,(2002) , 10.1038/NATURE01176
Carlos Barcia, Carmen María Ros, Valentina Annese, María Angeles Carrillo-de Sauvage, Francisco Ros-Bernal, Aurora Gómez, José Enrique Yuste, Carmen María Campuzano, Vicente de Pablos, Emiliano Fernandez-Villalba, María Trinidad Herrero, ROCK/Cdc42-mediated microglial motility and gliapse formation lead to phagocytosis of degenerating dopaminergic neurons in vivo Scientific Reports. ,vol. 2, pp. 809- 809 ,(2012) , 10.1038/SREP00809
Hemant Varma, Ai Yamamoto, Melissa R. Sarantos, Robert E. Hughes, Brent R. Stockwell, Mutant Huntingtin Alters Cell Fate in Response to Microtubule Depolymerization via the GEF-H1-RhoA-ERK Pathway * Journal of Biological Chemistry. ,vol. 285, pp. 37445- 37457 ,(2010) , 10.1074/JBC.M110.125542
Anne J. Ridley, Hugh F. Paterson, Caroline L. Johnston, Dagmar Diekmann, Alan Hall, The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell. ,vol. 70, pp. 401- 410 ,(1992) , 10.1016/0092-8674(92)90164-8
Jong Bae Park, Glenn Yiu, Shinjiro Kaneko, Jing Wang, Jufang Chang, Zhigang He, A TNF Receptor Family Member, TROY, Is a Coreceptor with Nogo Receptor in Mediating the Inhibitory Activity of Myelin Inhibitors Neuron. ,vol. 45, pp. 345- 351 ,(2005) , 10.1016/J.NEURON.2004.12.040
Daniel R. Rosen, Teepu Siddique, David Patterson, Denise A. Figlewicz, Peter Sapp, Afif Hentati, Deirdre Donaldson, Jun Goto, Jeremiah P. O'Regan, Han-Xiang Deng, Zohra Rahmani, Aldis Krizus, Diane McKenna-Yasek, Annarueber Cayabyab, Sandra M. Gaston, Ralph Berger, Rudolph E. Tanzi, John J. Halperin, Brian Herzfeldt, Raymond Van den Bergh, Wu-Yen Hung, Thomas Bird, Gang Deng, Donald W. Mulder, Celestine Smyth, Nigel G. Laing, Edwin Soriano, Margaret A. Pericak–Vance, Jonathan Haines, Guy A. Rouleau, James S. Gusella, H. Robert Horvitz, Robert H. Brown, Mutations in Cu/Zn superoxide dismutase gene are associated with familial amyotrophic lateral sclerosis Nature. ,vol. 362, pp. 59- 62 ,(1993) , 10.1038/362059A0