Stereocontrolled Synthesis of Enantiopure Substituted 4-Aminopyrrolidin-2-ones
作者： Nicole Langlois , Olivier Calvez , Marie-Odile Radom
DOI: 10.1016/S0040-4039(97)10216-7
关键词: Benzylamine 、 Enantiopure drug 、 Chemistry 、 Conjugate 、 Lactam 、 Stereochemistry
摘要: Abstract The highly diastereoselective conjugate addition of N -benzylhydroxylamine and benzylamine to α,β-unsaturated lactam 3 provided an efficient entry enantiopure (4 S ,5 )-4-amino-5-hydroxymethylpyrrolidin-2-ones. © 1997 Elsevier Science Ltd.
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