Dilated-Hypokinetic Evolution of Hypertrophic Cardiomyopathy: Prevalence, Incidence, Risk Factors, and Prognostic Implications in Pediatric and Adult Patients

摘要: Objectives This study sought to investigate the incidence, risk factors, and prognosis of dilated-hypokinetic evolution in a large cohort patients with hypertrophic cardiomyopathy (HCM) followed up at cardiology center serving both pediatric adult population. Background The available data on this HCM mainly regards prevalence (rather than incidence) adults, very little being known about Methods A total 222 consecutive (65% men, 19% ≤18 years old) were prospectively evaluated for mean follow-up 11 ± 9 years. Results diagnosis was made 12 first evaluation (11 without previous septal myectomy surgery; prevalence, 4.9%). Twelve 210 classic underwent (incidence, 5.3/1,000 patient-years). Patients prevalent/incident younger (32 14 vs. 41 21 years, p = 0.04) more often had family history (61% 26%, 0.002) or sudden death (43% 19%, 0.01) respect who maintained HCM. Moreover, they showed greater interventricular septum (23 3 mm 19 6 mm, 0.004) posterior wall (15 13 4 0.006) thickness. Cardiovascular death-free survival lower among (p Conclusions Dilated-hypokinetic is rare but not exceptional Young age diagnosis, HCM, thickness are incremental factors which carries an ominous prognosis.