Cell lineage distribution atlas of the human stomach reveals heterogeneous gland populations in the gastric antrum
作者： Eunyoung Choi , Joseph T Roland , Brittney J Barlow , Ryan O'Neal , Amy E Rich
DOI: 10.1136/GUTJNL-2013-305964
关键词: Gastrin 、 G cell 、 Biology 、 Pathology 、 Myoepithelial cell 、 Gastric glands 、 Gastric chief cell 、 Pyloric Antrum 、 Gastric mucosa 、 Foveolar cell 、 Anatomy 、 Gastroenterology
摘要: Objective The glands of the stomach body and antral mucosa contain a complex compendium cell lineages. In lower mammals, distribution oxyntic define anatomical regions within stomach. We examined in detail full range lineages human Design determined gastric gland with specific immunocytochemical markers entire specimens from three non-obese organ donors. Results antrum were defined by presence ghrelin gastrin cells, respectively. Concentrations somatostatin cells observed proximal Parietal seen all as well over 50% glands. MIST1 expressing chief predominantly although individual also showed cells. While classically described deep mucous without any parietal we substantial population mixed type containing both G throughout antrum. Conclusions Enteroendocrine show distinct patterns localisation existence indicates that may be functionally chimeric assembled multiple stem populations.
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