Autotaxin: a secreted autocrine/paracrine factor that promotes glioma invasion
作者： Dominique B. Hoelzinger , Mitsutoshi Nakada , Tim Demuth , Tyler Rosensteel , Linsey B. Reavie
DOI: 10.1007/S11060-007-9480-6
关键词: Autotaxin 、 Paracrine signalling 、 Biochemistry 、 Cell culture 、 Autocrine Motility Factor 、 Lysophosphatidic acid 、 Biology 、 Cancer research 、 Autocrine signalling 、 Population 、 Cell
摘要: Glioblastoma multiforme (GBM) is inherently invasive, and it from the invasive cell population that tumor recurs. The GBM invasion transcriptome reveals over-expression of various autocrine factors could act as motility drivers, such autotaxin (ATX). Some these also have paracrine roles, modulating behavior cells in peri-tumoral brain parenchyma. ATX generates lysophosphatidic acid (LPA), which signals through LPA receptors expressed by well astrocytes, oligodendrocytes (ODC) microglia; their activation manifest specific effects. stimulates vitro ex vivo assays. activity enhances adhesion expressing LPA1 receptor, stimulating rac activation. secreted can effects: results reduced ODC adhesion. monolayer showed U87 U251 invaded an significantly more than depleted or inactive ATX, suggesting secreting find ODCs less a barrier do not express ATX. Secreted drive roles; one other dis-adhesion.
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