Genomic mutation rates: what high-throughput methods can tell us.

摘要: High-throughput DNA analyses are increasingly being used to detect rare mutations in moderately sized genomes. These methods have yielded genome mutation rates that markedly higher than those obtained using pre-genomic strategies. Recent work a variety of organisms has shown rate is strongly affected by sequence context and position. observations suggest high-throughput will ultimately allow researchers identify trans-acting factors cis sequences underlie variation. Such should provide insights on how variability can impact organization disease progression.