Citrus Fruit Intake Substantially Reduces the Risk of Esophageal Cancer

摘要: Many epidemiologic studies indicate a potential association between fruit and vegetable intake various cancers. The purpose of this meta-analysis is to investigate the citrus esophageal cancer risk. authors conducted comprehensive search on PubMed, EMBASE, Cochrane Library from inception until July 2014. Studies presenting information about were analyzed. extracted categories intake, study-specific odds ratio or relative risk, P value associated 95% confidence intervals for highest versus lowest dietary level. was quantified using standard errors with random-effects model. Thirteen case-control 6 cohort eligible inclusion. Citrus may significantly reduce risk (summary = 0.63; interval 0.52-0.75; 0), without notable publication bias (intercept -0.79, 0.288) significant heterogeneity across (I 52%). results suggest an inverse effect consistent studies. Larger prospective rigorous methodology should be considered validate fruits cancer.