Stress et transition psychotique : revue de la littérature

作者: B. Chaumette , O. Kebir , C. Mam Lam Fook , J. Bourgin , B.P. Godsil

DOI: 10.1016/J.ENCEP.2015.10.001

关键词: GynecologyPsychological stressUltra high riskMedicine

摘要: Resume Le stress psychologique induit une deregulation de l’axe hypothalamo-hypophyso-surrenalien (HHS) qui entraine perturbation la physiologie cerebrale. Ces elements biologiques ont conduit a promouvoir l’hypothese selon laquelle le pourrait influencer l’emergence pathologies psychiatriques et en particulier schizophrenie (transition psychotique). Cette revue litterature vise realiser un etat des lieux question du dans psychose methodes d’investigation notamment dosage cortisol. role HHS declenchement est discute. etre cause specifique l’entree maladie ou refleter uniquement detresse liee symptomes. La s’est attachee mettre relief les etudes sur l’implication differentes phases psychotique. met evidence suivant modele vulnerabilite–stress. deregulation, presente phase prodromique (sujets ultra-haut risque) premier episode psychotique, favoriser pathologie. En effet, donc reponse au semble associee symptomes psychotiques. Toutefois, mecanismes precis sont encore mal connus necessitent plus amples investigations, d’autant que nombreux facteurs confondants modulent taux cortisol stress, y compris consommation cannabis prise traitements. outre, reactivite modulee par genetiques. decouverte associes transition psychotique apporter aide diagnostique pronostique ainsi cibles therapeutiques.

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