Generation of specific anti-melanoma reactivity by stimulation of human tumor-infiltrating lymphocytes with MAGE-1 synthetic peptide.
作者： Michael L. Salgaller , Jeffrey S. Weber , Scott Koenig , John R. Yannelli , Steven A. Rosenberg
DOI: 10.1007/BF01525316
关键词: Antigen 、 Tumor-infiltrating lymphocytes 、 Immunotherapy 、 CTL* 、 Melanoma 、 Cytolysis 、 Epitope 、 Interleukin 2 、 Immunology 、 Biology 、 Cancer research
摘要: The MAGE-1 gene encodes a tumor-specific antigen, MZ2-E, which is recognized by cloned, specific cytolytic T cells (CTL) derived from the peripheral blood of patient with melanoma. We have produced MAGE-1-specific CTL line tumor-infiltrating lymphocytes (TIL) melanoma weekly restimulation autologous EBV-B pulsed synthetic HLA-A1-restricted epitope nonapeptide EADPTGHSY. 1277.A TIL grew in long-term culture low-dose interleukin-2 (IL-2) and IL-4, exhibited antigen-specific, MHC-class-I-restricted lysis HLA-A1-bearing MAGE-1+ cell lines. Cytolysis target decapeptide KEADPTGHSY was superior to that immunodominant nonapeptide. Single amino-acid or even side-chain substitutions nonamer abrogated cytolysis. specifically secreted tumor necrosis factor alpha after co-incubation HLA-A1-expressing lines fresh tumor. These data suggest tumor-antigen-specific, MHC-restricted may be grown presence peptides expanded for adoptive immunotherapy patients.
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