Inducing precocious anaphase in cultured mammalian cells.
作者： Julie C. Canman , E.D. Salmon , Guowei Fang
DOI: 10.1002/CM.10032
关键词: Cell biology 、 Spindle checkpoint 、 Kinetochore 、 Prometaphase 、 Securin 、 Anaphase 、 Cell cycle checkpoint 、 Anaphase lag 、 Biology 、 Separase
摘要: The spindle checkpoint, which prevents anaphase onset upon damage or incorrect chromosome alignment, presents a problem for experimental analysis of protein function in and cytokinesis. This is because the functional disruption many proteins before can activate this preventing subsequent cell cycle events. paper compares new old methods overriding checkpoint prometaphase mammalian tissue culture cells. Cell Motil. Cytoskeleton 52:61–65, 2002. © 2002 Wiley-Liss, Inc.
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