The effect of reported prostaglandin synthetase inhibitors on estradiol-stimulated uterine prostaglandin biosynthesis in vivo in the ovariectomized rat.
作者： V.Craig Jordan , V.Daniel Castracane
DOI: 10.1016/0090-6980(76)90140-4
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摘要: Abstract Aspirin, indomethacin and naproxen have been shown to inhibit the release of prostaglandins E F (PGE PGF) from estradiol-stimulated uterus progesterone-pretreated ovariectomized rats. Under present experimental conditions (1 mg/rat) was found be a potent inhibitor PGF biosynthesis, but duration action less than 24 hours, after which rebound above control levels observed. The compounds were without effect on increases in uterine wet weight. Δ′THC did not PG biosynthesis produced significant rise (P
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sci-hub.se 参考文章(17)
R.V. Tomlinson, H.J. Ringold, M.C. Qureshi, E. Forchielli, Relationship between inhibition of prostaglandin synthesis and drug efficacy: Support for the current theory on mode of action of aspirin-like drugs Biochemical and Biophysical Research Communications. ,vol. 46, pp. 552- 559 ,(1972) , 10.1016/S0006-291X(72)80174-8
E.W. Horton, I.H.M. Main, Differences in the effects of prostaglandin F2a, a constituent of cerebral tissue, and prostaglandin E1 on conscious cats and chicks Neuropharmacology. ,vol. 4, pp. 65- ,(1965) , 10.1016/0028-3908(65)90029-8
W. FENIUK, B.J. LARGE, THE EFFECTS OF PROSTAGLANDINS E1, E2 AND F2αON VAGAL BRADYCARDIA IN THE ANAESTHETIZED MOUSE British Journal of Pharmacology. ,vol. 55, pp. 47- 49 ,(1975) , 10.1111/J.1476-5381.1975.TB07608.X
C. H. Hockman, R. G. Perrin, H. Kalant, Electroencephalographic and Behavioral Alterations Produced by Δ1-Tetrahydrocannabinol Science. ,vol. 172, pp. 968- 970 ,(1971) , 10.1126/SCIENCE.172.3986.968
Kim Solez, Jennifer A. Fox, Marilyn Miller, Robert H. Heptinstall, Effects of indomethacin on renal inner medullary plasma flow Prostaglandins. ,vol. 7, pp. 91- 98 ,(1974) , 10.1016/0090-6980(74)90126-9
JAMES W. AIKEN, Aspirin and Indomethacin Prolong Parturition in Rats: Evidence that Prostaglandins Contribute to Expulsion of Foetus Nature. ,vol. 240, pp. 21- 25 ,(1972) , 10.1038/240021A0
Bernard M. Jaffe, Harold R. Behrman, Charles W. Parker, Radioimmunoassay measurement of prostaglandins E, A, and F in human plasma. Journal of Clinical Investigation. ,vol. 52, pp. 398- 405 ,(1973) , 10.1172/JCI107196
B. BARCIKOWSKI, J.C. CARLSON, L. WILSON, J.A. McCRACKEN, The Effect of Endogenous and Exogenous Estradiol-17β on the Release of Prostaglandin F2α from the Ovine Uterus Endocrinology. ,vol. 95, pp. 1340- 1349 ,(1974) , 10.1210/ENDO-95-5-1340
M. Galanter, R. J. Wyatt, L. Lemberger, H. Weingartner, T. B. Vaughan, W. T. Roth, Effects on humans of 9 -tetrahydrocannabinol administered by smoking. Science. ,vol. 176, pp. 934- 936 ,(1972) , 10.1126/SCIENCE.176.4037.934
Sumner Burstein, Amiram Raz, Inhibition of prostaglandin E2 biosynthesis by Δ1-tetrahydrocannabinol Prostaglandins. ,vol. 2, pp. 369- 374 ,(1972) , 10.1016/S0090-6980(72)80044-3