Genetic Tumor Markers With Prognostic Impact in Dukes’ Stages B and C Colorectal Cancer Patients
作者： Chieu B. Diep , Lin Thorstensen , Gunn Iren Meling , Eva Skovlund , Torleiv O. Rognum
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摘要: Purpose: To examine several genetic changes in primary colorectal carcinomas (CRCs) from patients with 10 years of follow-up and associate the findings clinicopathologic variables. Material Methods: DNA 220 CRCs were analyzed for allelic imbalances at 12 loci on chromosome arms 1p, 14q, 17p, 18q, 20q, microsatellite instability (MSI) status was determined. The clinical significance tumor protein 53 (TP53) mutations re-evaluated. Results: Patients tumors containing 17p or 18q deletions had shorter survival than those without these alterations (P = .021, P .008, respectively). This also significant Dukes’ B group .025, .010, Furthermore, showing losses both revealed an even poorer disease outcome either loss. low increase 20q copy number their longer compared .009) a high increa...
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