Regulation of DNA repair in hypoxic cancer cells
作者： Ranjit S. Bindra , Meredith E. Crosby , Peter M. Glazer
DOI: 10.1007/S10555-007-9061-3
关键词:
摘要: Emerging evidence indicates that the tumor microenvironmental stress of hypoxia can induce genetic instability in cancer cells. We and others have found expression levels key genes within DNA mismatch repair (MMR) homologous recombination (HR) pathways are coordinately repressed by hypoxia. These decreases associated with functional impairments both MMR HR under hypoxic conditions, thus they represent a possible mechanistic explanation for observed phenomenon hypoxia-induced instability. In parallel, studies also indicate several damage response factors activated to subsequent reoxygenation, including ATM/ATR, Chkl/Chk2 BRCA1. Taken together, these findings reveal induces unique cellular involving an initial, acute followed chronic prolonged which selected suppressed. this review, we discuss mechanisms involved, as well consequences progression microenvironment.
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