Neuroimaging in identifying focal cortical dysplasia and prognostic factors in pediatric and adolescent epilepsy surgery

摘要: Summary Purpose:  The purpose of this study is to determine the sensibility each imaging tool in identifying focal cortical dysplasia (FCD) children and adolescents with epilepsy define prognostic factors pediatric adolescent surgery. Methods:  We identified 48 FCD who underwent resective surgery analyzed their preoperative data. results various anatomic functional neuroimaging studies were compared for accuracy locating lesion. also investigated clinical that affected outcome surgical treatment. Key Findings:  Brain magnetic resonance (MRI) was able localize 30 patients fluorodeoxyglucose positron emission tomography (FDG-PET) and/or subtraction ictal single photon computed (SPECT) coregistered MRI provided additional information helped lesion 13 patients. When comparing pathologic between a mild malformation development (MCD) type I II, we noted strong tendency have abnormalities (p = 0.005). In addition, severe features (Palmini’s classification, II) (p = 0.025) showed significant correlation better outcome. To primary epileptogenic area, interictal epileptiform discharges multimodal helpful, younger age at time operation could aid more favorable outcomes (p = 0.048). Significance:  Our relationship grade detectability by brain MRI. early can be justified showing advanced even extensive higher rate success.