Neuroprotective effects of the immunomodulatory drug Setarud on cerebral ischemia in male rats
作者： Farzaneh Dehghanian , Majid Asadi-Shekaari , Nasser Zangiabadi , Farzaneh Vafaee , Fatemeh Mehdi Pour
DOI: 10.3969/J.ISSN.1673-5374.2012.27.001
关键词:
摘要: Anti-inflammatory and anti-oxidant agents can alleviate ischemic cerebral injury. The immunomodulary drug Setarud, which is composed of herbal extracts including Rosa canina, Urtica dioica Tanacetum vulgare, supplemented with selenium exhibits anti-inflammatory properties. Therefore, we hypothesized that Setarud will have a neuroprotective effect against To validate this hypothesis, rats were intraperitoneally administered 0.66 mL/kg for 30 minutes after middle artery occlusion. Triphenyltetrazolium chloride staining showed could reduce infarct volume subjected to ischemia. Transmission electron microscopy hematoxylin-eosin results the degenerative changes in cortical neurons inclined plate test prehensile significantly improve motor function These findings suggest shows effects brain
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