CD8+ T cell contraction is controlled by early inflammation

摘要: Pathogen-specific CD8+ T cells expand in number after infection and then their numbers invariably contract by 90–95%, leaving a stable memory cell pool. The chief features of this response are programmed early infection; however, the factors regulating contraction mostly undefined. Here we show that antibiotic treatment before Listeria monocytogenes induced protective similar to those control infected mice, pathway without contraction. absence correlated with decreased inflammation interferon-γ production an increased fraction expressing interleukin 7 receptor at peak response. Thus, is controlled but not essential for generation infection.