Assessment of iron status

摘要: Abstract Objective: To review the clinical assessment of iron deficiency and excess. Conclusions: Two key iron-related proteins in human body are ferritin, which is storage protein, transferrin receptor, controls entry iron-bearing to cells. Intact ferritin truncated transferrin-receptor molecules present serum direct quantitative proportion their total tissue content. Ferritin production precisely reciprocally regulated at a posttranscriptional level. This achieved by an iron-responsive element-binding protein that interacts with elements mRNA each, but contrary effects. Increases reflect increased increases receptor cellular deficits. The combined use these two measurements allows accurate definition entire range status. valid even situations where status has been notoriously problematic, including periods rapid growth, pregnancy, conditions associated inflammation, trained athletes.